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Expression of protease-activated receptors on platelets in healthy individuals
Rui ZHU, Lin SHEN
《医学前沿(英文)》 2009年 第3卷 第2期 页码 236-239 doi: 10.1007/s11684-009-0040-7
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
《医学前沿(英文)》 2019年 第13卷 第1期 页码 69-82 doi: 10.1007/s11684-018-0677-1
Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapy. However, the good efficacy of CATs is rarely reported in clinical applications because CATs have no or very low antigen specificity. The low-efficacy problem can be resolved using T cell antigen receptor-engineered CAT (TCR-CAT). Herein, we demonstrate that NY-ESO-1157–165 HLA-A*02:01-specific high-affinity TCR (HAT)-transduced CATs can specifically kill cancer cells with good efficacy. With low micromolar range dissociation equilibrium constants, HAT-transduced CATs showed good specificity with no off-target killing. Furthermore, the high-affinity TCR-CATs delivered significantly better activation and cytotoxicity than the equivalent TCR-engineered T cells (TCR-Ts) in terms of interferon-g and granzyme B production and in vitro cancer cell killing ability. TCR-CAT may be a very good alternative to the expensive TCR-T, which is considered an effective personalized cyto-immunotherapy.
关键词: cytokine-activated T cells high-affinity T cell receptor cancer immunotherapy TCR-CAT
Toll-like receptors in innate immunity and infectious diseases
Min-Hao WU, Ping ZHANG, Xi HUANG,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 385-393 doi: 10.1007/s11684-010-0600-x
关键词: Toll-like receptors innate immunity infectious disease inflammation
Group III metabotropic glutamate receptors and drug addiction
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 445-451 doi: 10.1007/s11684-013-0291-1
Neuroadaptations of glutamatergic transmission in the limbic reward circuitry are linked to persistent drug addiction. Accumulating data have demonstrated roles of ionotropic glutamate receptors and group I and II metabotropic glutamate receptors (mGluRs) in this event. Emerging evidence also identifies Gαi/o-coupled group III mGluRs (mGluR4/7/8 subtypes enriched in the limbic system) as direct substrates of drugs of abuse and active regulators of drug action. Auto- and heteroreceptors of mGluR4/7/8 reside predominantly on nerve terminals of glutamatergic corticostriatal and GABAergic striatopallidal pathways, respectively. These presynaptic receptors regulate basal and/or phasic release of respective transmitters to maintain basal ganglia homeostasis. In response to operant administration of common addictive drugs, such as psychostimulants (cocaine and amphetamine), alcohol and opiates, limbic group III mGluRs undergo drastic adaptations to contribute to the enduring remodeling of excitatory synapses and to usually suppress drug seeking behavior. As a result, a loss-of-function mutation (knockout) of individual group III receptor subtypes often promotes drug seeking. This review summarizes the data from recent studies on three group III receptor subtypes (mGluR4/7/8) expressed in the basal ganglia and analyzes their roles in the regulation of dopamine and glutamate signaling in the striatum and their participation in the addictive properties of three major classes of drugs (psychostimulants, alcohol, and opiates).
关键词: group III metabotropic glutamate receptors cocaine amphetamine alcohol opiate
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 465-472 doi: 10.1007/s11684-016-0482-7
Previous studies have demonstrated the effects of different afferent fibers on electroacupuncture (EA)-induced analgesia. However, contributions of functional receptors expressed on afferent fibers to the EA analgesia remain unclear. This study investigates the roles of acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) receptors in EA-induced segmental and systemic analgesia. Effects of EA at acupoint ST36 with different intensities on the C-fiber reflex and mechanical and thermal pain thresholds were measured among the ASIC3−/−, TRPV1−/−, and C57BL/6 mice. Compared with C57BL/6 mice, the ipsilateral inhibition of EA with 0.8 C-fiber threshold (0.8Tc) intensity on C-fiber reflex was markedly reduced in ASIC3−/− mice, whereas the bilateral inhibition of 1.0 and 2.0Tc EA was significantly decreased in TRPV1−/− mice. The segmental increase in pain thresholds induced by 0.3 mA EA was significantly reduced in ASIC3−/− mice, whereas the systemic enhancement of 1.0 mA EA was markedly decreased in TRPV1−/− mice. Thus, segmental analgesia of EA with lower intensity is partially mediated by ASIC3 receptor on Aβ-fiber, whereas systemic analgesia induced by EA with higher intensity is more likely induced by TRPV1 receptor on Ad- and C-fibers.
关键词: electroacupuncture analgesia ASIC3 TRPV1 C-fiber reflex
嵌合抗原受体和调节性T细胞——移植中人类白细胞抗原特异性免疫抑制的潜力 Review
Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa
《工程(英文)》 2022年 第10卷 第3期 页码 30-43 doi: 10.1016/j.eng.2021.10.018
嵌合抗原受体(CAR)是基因工程领域的一项突破,它彻底改变了过继细胞疗法(ACT)领域。表达这些受体的细胞通过在合成的CAR构建体中包含抗原特异性结合区域而被重新定向到预定的靶点。程序化特异性细胞在肿瘤学领域的优势已被临床证明,与同类未修饰的细胞相比,这种细胞具有更高的准确性、效力与更少的脱靶效应。与常规T细胞(Tconvs)不同,调节性T细胞(Treg)在抑制免疫激活和调节宿主免疫反应方面发挥着重要作用。Treg 中CAR的表达被认为是治疗自身免疫和炎症性疾病、移植物抗宿主病(GVHD)和器官移植排斥反应的一种方法。在后者中,它们作为同种异体移植受者免疫耐受的介质具有巨大的潜力。然而,目前对CAR-Treg 工程的研究非常有限,并且关于治疗用途的最佳设计存在不确定性。本文综述了CAR-Treg 发展的理论基础、其对人类移植的意义、潜在的设计、安全性考虑因素,以及迄今为止CAR-Treg在移植模型中的对比。
关键词: 嵌合抗原受体(CAR) 调节性T细胞 异性免疫 CAR设计 基因编辑
Advances in newly developing therapy for chronic hepatitis C virus infection
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 166-174 doi: 10.1007/s11684-014-0334-2
Chronic hepatitis C virus (HCV) infection afflicts a reported 170 million people worldwide and is often complicated by cirrhosis and hepatocellular carcinoma. Morbidity and mortality are decreased with the successful treatment of chronic HCV infection. Increased understanding of the HCV has allowed further development of new direct-acting antiviral (DAA) agents against the HCV and has also allowed the development of IFN-free oral treatment regimens. In late 2013 the first nucleotide polymerase inhibitor regimen with RBV alone for genotypes 2/3 and in combination with a 12-week regimen of PEG-IFN+RBV for genotypes 1, 4 was approved for use in the US. A number of promising new DAA regimens which are IFN-free are in phase 3 development and the first will likely be approved for use in the US in 2014. The currently approved regimens are discussed in detail and currently available data on future regimens are reviewed herein.
关键词: direct-acting antiviral (DAA) nucleotide polymerase inhibitors protease inhibitors
Adsorption of benzene and toluene from waste gas using activated carbon activated by ZnCl
Leila KARIMNEZHAD,Mohammad HAGHIGHI,Esmaeil FATEHIFAR
《环境科学与工程前沿(英文)》 2014年 第8卷 第6期 页码 835-844 doi: 10.1007/s11783-014-0695-4
关键词: Chemical activation activated carbon textural characterization adsorption benzene toluene
《环境科学与工程前沿(英文)》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1419-1
• Pore structure affects biologically activated carbon performance.
关键词: Granular activated carbon Biologically activated carbon filter Bacterial community structure Pore structure
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 76-84 doi: 10.1007/s11684-015-0426-7
Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are important contributors to thrombosis, especially in patients with antiphospholipid syndrome (APS). However, the mechanism by which anti-β2GP I antibodies are involved in the pathogenesis of thrombosis is not fully understood. In this report, we investigated the role of anti-β2GP I antibodies in complexes with β2GP I as mediators of platelet activation, which can serve as a potential source contributing to thrombosis. We examined the involvement of the apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I bα) in platelet activation induced by the anti-β2GP I /β2GP I complex. The interaction between the anti-β2GP I /β2GP I complex and platelets was examined using in vitro methods, in which the Fc portion of the antibody was immobilized using protein A coated onto a microtiter plate. Platelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression and thromboxane B2 production as well as p38 mitogen-activated protein kinase phosphorylation. Our results revealed that the anti-β2GP I /β2GP I complex was able to activate platelets, and this activation was inhibited by either the anti-GP I bα antibody or the apoER2' inhibitor. Results showed that the anti-β2GP I /β2GP I complex induced platelet activation via GP I bα and apoER2', which may then contribute to the prothrombotic tendency in APS patients.
关键词: anti-β2GP I /β2GP I complex platelet GP I bα apoER2' thrombosis
Removal of phenol by powdered activated carbon adsorption
Yan MA, Naiyun GAO, Wenhai CHU, Cong LI
《环境科学与工程前沿(英文)》 2013年 第7卷 第2期 页码 158-165 doi: 10.1007/s11783-012-0479-7
关键词: phenol powdered activated carbon adsorption kinetics isotherms
Kinetics and thermodynamics of the phosphine adsorption on the modified activated carbon
Bingnan REN
《化学科学与工程前沿(英文)》 2011年 第5卷 第2期 页码 203-208 doi: 10.1007/s11705-010-0571-0
关键词: adsorption PH3 activated carbon kinetics thermodynamics
Responses of microbial interactions to elevated salinity in activated sludge microbial community
《环境科学与工程前沿(英文)》 2023年 第17卷 第5期 doi: 10.1007/s11783-023-1660-x
● Salinity led to the elevation of NAR over 99.72%.
关键词: Elevated salinity Activated sludge system Pollution removal Microbial interactions Competitive relationship
《医学前沿(英文)》 2023年 第17卷 第2期 页码 275-289 doi: 10.1007/s11684-022-0945-y
关键词: epidermal growth factor receptor ErbB receptors HM781-36B nasopharyngeal carcinoma molecular targeted therapy cisplatin
A hybrid membrane process for simultaneous thickening and digestion of waste activated sludge
Zhiwei WANG, Qiaoying WANG, Zhichao WU, Xinhua WANG,
《环境科学与工程前沿(英文)》 2010年 第4卷 第3期 页码 272-279 doi: 10.1007/s11783-010-0234-x
关键词: membrane filtration sludge digestion sludge thickening waste activated sludge
标题 作者 时间 类型 操作
Expression of protease-activated receptors on platelets in healthy individuals
Rui ZHU, Lin SHEN
期刊论文
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
期刊论文
Toll-like receptors in innate immunity and infectious diseases
Min-Hao WU, Ping ZHANG, Xi HUANG,
期刊论文
Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia
null
期刊论文
Adsorption of benzene and toluene from waste gas using activated carbon activated by ZnCl
Leila KARIMNEZHAD,Mohammad HAGHIGHI,Esmaeil FATEHIFAR
期刊论文
Influence of pore structure on biologically activated carbon performance and biofilm microbial characteristics
期刊论文
Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two receptors
null
期刊论文
Removal of phenol by powdered activated carbon adsorption
Yan MA, Naiyun GAO, Wenhai CHU, Cong LI
期刊论文
Kinetics and thermodynamics of the phosphine adsorption on the modified activated carbon
Bingnan REN
期刊论文
Responses of microbial interactions to elevated salinity in activated sludge microbial community
期刊论文
A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal carcinoma
期刊论文